Footmarks of Innate Immunity in the Ovary and Cytokeratin-Positive Cells as Potential Dendritic Cells
The cyclic ovary can be seen as a site of tissue damage, repair and precisely controlled tissue homeostasis, as long ovulation and luteolysis can be compared with acute and chronic inflammation. Innate immunity appears to be a powerful force in the endocrine system, representing a novel concept. In...
Clasificación: | Libro Electrónico |
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Autor principal: | |
Autor Corporativo: | |
Formato: | Electrónico eBook |
Idioma: | Inglés |
Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2011.
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Edición: | 1st ed. 2011. |
Colección: | Advances in Anatomy, Embryology and Cell Biology,
209 |
Temas: | |
Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- 1 Background
- 1.1 Innate Immunity, Toll-like Receptors (TLR), and Danger Signals 1.2 The Ovary, Tissue Remodelling, and Immune Privilege
- 1.3 Design
- 2 Material and Methods
- 2.1 Cyclic and Superovulated Ovaries from Rats, Hamsters, Rabbits as well as Canine, Bovine and Human Ovaries
- 2.1.1 Fibrinolytic Activity and Implants on the Chick Chorioallantois Membrane (CAM)
- 2.1.2 Fixation, Staining and Counting Ovarian Structures
- 2.2 Cell Culture Subtypes from Follicles Derived from Patients Under in Vitro Fertilization Therapy
- 2.3 Cell Culture Subtypes from Bovine Corpus Luteum (CL) and Characterization
- 3 Footmarks of Innate Immunity
- 3.1 The Complement System as Danger Sensor in General and in the Ovary
- 3.2 Mild Danger with Mild Response
- 3.2.1 Implantation of the Ovary into the CAM
- 3.2.2 Follicular Atresia
- 3.3 Moderate Danger by Preovulatory Follicle Rupture and Acute Inflammation with Eosinophils
- 3.3.1 Recruitment of Eosinophils and Substance P-Like Expression
- 3.4 Severe Danger in Superovulated Ovaries with Intra-Ovarian Oocyte Release and Thrombus Formation
- 4 Cytokeratin-Positive (CK+) cell as Potential Dendritic Cells
- 4.1 Dendritic cells, the TLR System in General and in the Ovary
- 4.2 Localisation of CK+ Cells in the Intact Ovary
- 4.2.1 Follicles in Foetal and Adult Ovaries
- 4.2.2 Corpus Luteum
- 5 Characterization of Isolated CK+ Cells
- 5.1 CK+ Cells from Preovulatory Follicles with TLR4 Expression
- 5.2 CK+ Cells from CL in Comparison to CK-Negative (CK-) Cells
- 5.2.1 Effects of Interferon-gamma on CK+ Cells from the CL Compared to CK- Cells and to Surface Epithelial Cells
- 5.2.2 Reflections on Quality of the CK+ Type 1 and Similarity with the Type 5
- 6 Working Hypothesis and Challenges
- 7 Clinical Perspectives
- 8 Concluding Summary and Remarks
- References
- Subject index.