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Toxic Plant Proteins
Many plants produce enzymes collectively known as ribosome-inactivating proteins (RIPs). RIPs catalyze the removal of an adenine residue from a conserved loop in the large ribosomal RNA. The adenine residue removed by this depurination is crucial for the binding of elongation factors. Ribosomes modi...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2010.
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| Edición: | 1st ed. 2010. |
| Colección: | Plant Cell Monographs,
18 |
| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
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| 001 | 978-3-642-12176-0 | ||
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| 005 | 20220118232712.0 | ||
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| 008 | 100721s2010 gw | s |||| 0|eng d | ||
| 020 | |a 9783642121760 |9 978-3-642-12176-0 | ||
| 024 | 7 | |a 10.1007/978-3-642-12176-0 |2 doi | |
| 050 | 4 | |a QK861-899 | |
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| 082 | 0 | 4 | |a 572.2 |2 23 |
| 245 | 1 | 0 | |a Toxic Plant Proteins |h [electronic resource] / |c edited by J. Michael Lord, Martin R. Hartley. |
| 250 | |a 1st ed. 2010. | ||
| 264 | 1 | |a Berlin, Heidelberg : |b Springer Berlin Heidelberg : |b Imprint: Springer, |c 2010. | |
| 300 | |a X, 270 p. 41 illus., 12 illus. in color. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a Plant Cell Monographs, |x 1861-1362 ; |v 18 | |
| 505 | 0 | |a Evolution of Plant Ribosome-Inactivating Proteins -- RNA N-Glycosidase Activity of Ribosome-Inactivating Proteins -- Enzymatic Activities of Ribosome-Inactivating Proteins -- Type I Ribosome-Inactivating Proteins from Saponaria officinalis -- Type 1 Ribosome-Inactivating Proteins from the Ombú Tree (Phytolacca dioica L.) -- Sambucus Ribosome-Inactivating Proteins and Lectins -- Ribosome-Inactivating Proteins from Abrus pulchellus -- Ribosome-Inactivating Proteins in Cereals -- Ribosome Inactivating Proteins and Apoptosis -- The Synthesis of Ricinus communis Lectins -- How Ricin Reaches its Target in the Cytosol of Mammalian Cells -- Ribosome-Inactivating Protein-Containing Conjugates for Therapeutic Use. | |
| 520 | |a Many plants produce enzymes collectively known as ribosome-inactivating proteins (RIPs). RIPs catalyze the removal of an adenine residue from a conserved loop in the large ribosomal RNA. The adenine residue removed by this depurination is crucial for the binding of elongation factors. Ribosomes modified in this way are no longer able to carry out protein synthesis. Most RIPs exist as single polypeptides (Type 1 RIPs) which are largely non-toxic to mammalian cells because they are unable to enter them and thus cannot reach their ribosomal substrate. In some instances, however, the RIP forms part of a heterodimer where its partner polypeptide is a lectin (Type 2 RIPs). These heterodimeric RIPs are able to bind to and enter mammalian cells. Their ability to reach and modify ribosomes in target cells means these proteins are some of the most potently cytotoxic poisons found in nature, and are widely assumed to play a protective role as part of the host plant's defenses. RIPs are able to further damage target cells by inducing apoptosis. In addition, certain plants produce lectins lacking an RIP component but which are also cytotoxic. This book focuses on the structure/function and some potential applications of these toxic plant proteins. | ||
| 650 | 0 | |a Botanical chemistry. | |
| 650 | 0 | |a Cytology. | |
| 650 | 0 | |a Plant physiology. | |
| 650 | 0 | |a Botany. | |
| 650 | 1 | 4 | |a Plant Biochemistry. |
| 650 | 2 | 4 | |a Cell Biology. |
| 650 | 2 | 4 | |a Plant Physiology. |
| 650 | 2 | 4 | |a Plant Science. |
| 700 | 1 | |a Lord, J. Michael. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 700 | 1 | |a Hartley, Martin R. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9783642263774 |
| 776 | 0 | 8 | |i Printed edition: |z 9783642121753 |
| 776 | 0 | 8 | |i Printed edition: |z 9783642121777 |
| 830 | 0 | |a Plant Cell Monographs, |x 1861-1362 ; |v 18 | |
| 856 | 4 | 0 | |u https://doi.uam.elogim.com/10.1007/978-3-642-12176-0 |z Texto Completo |
| 912 | |a ZDB-2-SBL | ||
| 912 | |a ZDB-2-SXB | ||
| 950 | |a Biomedical and Life Sciences (SpringerNature-11642) | ||
| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||