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Transformative Concepts for Drug Design: Target Wrapping
In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to find, and successful t...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Autor Corporativo: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2010.
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| Edición: | 1st ed. 2010. |
| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy
- Wrapping Defects and the Architecture of Soluble Proteins
- Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins
- Wrapping Deficiencies and De-wetting Patterns in Soluble Proteins: A Blueprint for Drug Design
- Under-Wrapped Proteins in the Order-Disorder Twilight: Unraveling the Molecular Etiology of Aberrant Aggregation
- Evolution of Protein Wrapping and Implications for the Drug Designer
- Wrapping as a Selectivity Filter for Molecular Targeted Therapy: Preliminary Evidence
- Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects
- Wrapping Patterns as Universal Markers for Specificity in the Therapeutic Interference with Signaling Pathways
- Fulfilling a Therapeutic Imperative in Cancer Treatment: Control of Multi-target Drug Impact
- Inducing Folding By Crating the Target
- Wrapper Drugs as Therapeutic Editors of Side Effects
- Wrapper Drugs for Personalized Medicine
- Last Frontier and Back to the Drawing Board: Protein-Water Interfacial Tension in Drug Design.