Cargando…
miRNA Regulation of the Translational Machinery
The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencin...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2010.
|
| Edición: | 1st ed. 2010. |
| Colección: | Progress in Molecular and Subcellular Biology,
50 |
| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
| LEADER | 00000nam a22000005i 4500 | ||
|---|---|---|---|
| 001 | 978-3-642-03103-8 | ||
| 003 | DE-He213 | ||
| 005 | 20230810204509.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 100301s2010 gw | s |||| 0|eng d | ||
| 020 | |a 9783642031038 |9 978-3-642-03103-8 | ||
| 024 | 7 | |a 10.1007/978-3-642-03103-8 |2 doi | |
| 050 | 4 | |a QD415-436 | |
| 072 | 7 | |a PSB |2 bicssc | |
| 072 | 7 | |a SCI007000 |2 bisacsh | |
| 072 | 7 | |a PSB |2 thema | |
| 082 | 0 | 4 | |a 572 |2 23 |
| 245 | 1 | 0 | |a miRNA Regulation of the Translational Machinery |h [electronic resource] / |c edited by Robert E. Rhoads. |
| 250 | |a 1st ed. 2010. | ||
| 264 | 1 | |a Berlin, Heidelberg : |b Springer Berlin Heidelberg : |b Imprint: Springer, |c 2010. | |
| 300 | |a X, 115 p. 23 illus., 4 illus. in color. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a Progress in Molecular and Subcellular Biology, |x 2197-8484 ; |v 50 | |
| 505 | 0 | |a Understanding How miRNAs Post-Transcriptionally Regulate Gene Expression -- Translational Control of Endogenous MicroRNA Target Genes in -- Translational Inhibition by MicroRNAs in Plants -- Regulation of p27 mRNA Expression by MicroRNAs -- The Inhibitory Effect of Apolipoprotein B mRNA-Editing Enzyme Catalytic Polypeptide-Like 3G (APOBEC3G) and Its Family Members on the Activity of Cellular MicroRNAs -- MicroRNA-Mediated mRNA Deadenylation and Repression of Protein Synthesis in a Mammalian Cell-Free System -- miRNA Effects on mRNA Closed-Loop Formation During Translation Initiation. | |
| 520 | |a The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing. One consequence is mRNA-specific inhibition of protein synthesis. Evidence has been presented for diverse mechanisms, but there is not universal agreement in the field of how RISCs affect the translational machinery. The chapters collected in this volume represent contribution by leaders in the search to understand how miRNAs affect translation. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 (HIV-1). | ||
| 650 | 0 | |a Biochemistry. | |
| 650 | 0 | |a Cytology. | |
| 650 | 0 | |a Molecular genetics. | |
| 650 | 0 | |a Medicine |x Research. | |
| 650 | 0 | |a Biology |x Research. | |
| 650 | 1 | 4 | |a Biochemistry. |
| 650 | 2 | 4 | |a Cell Biology. |
| 650 | 2 | 4 | |a Molecular Genetics. |
| 650 | 2 | 4 | |a Biomedical Research. |
| 700 | 1 | |a Rhoads, Robert E. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9783642031045 |
| 776 | 0 | 8 | |i Printed edition: |z 9783642031021 |
| 776 | 0 | 8 | |i Printed edition: |z 9783642261404 |
| 830 | 0 | |a Progress in Molecular and Subcellular Biology, |x 2197-8484 ; |v 50 | |
| 856 | 4 | 0 | |u https://doi.uam.elogim.com/10.1007/978-3-642-03103-8 |z Texto Completo |
| 912 | |a ZDB-2-SBL | ||
| 912 | |a ZDB-2-SXB | ||
| 950 | |a Biomedical and Life Sciences (SpringerNature-11642) | ||
| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||