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Interferon: The 50th Anniversary

Over the last half of century interferon (IFN), originally discovered as an antiviral protein, has developed from an inhibitor of viral replication to a major force in the antiviral response. Initially studied only by few virologists, IFN was generally considered as a poorly defined protein of limit...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Pitha, Paula M. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2007.
Edición:1st ed. 2007.
Colección:Current Topics in Microbiology and Immunology, 316
Temas:
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Refletions
  • How to Chase a Red Herring and Come up with a Smallmouth Bass
  • Interferon Research BC (Before Cloning)
  • Purification and Cloning of Interferon Alpha
  • Interferons and Their Signaling Pathways
  • Type I Interferon: The Ever Unfolding Story
  • The Receptor of the Type I Interferon Family
  • IFN-?: Recent Advances in Understanding Regulation of Expression, Biological Functions, and Clinical Applications
  • Cell Type-Specific Signaling in Response to Interferon-?
  • Interferon Research: Impact on Understanding Transcriptional Control
  • Recognition of Pathogens, Molecular Mechanism of Interferon Beta Induction
  • TLR-Mediated Activation of Type I IFN During Antiviral Immune Responses: Fighting the Battle to Win the War
  • Regulation of Antiviral Innate Immune Responses by RIG-I Family of RNA Helicases
  • Beyond Double-Stranded RNA-Type I IFN Induction by 3pRNA and Other Viral Nucleic Acids
  • Interferon-Induced Genes
  • The Interferon-Stimulated Genes: Targets of Direct Signaling by Interferons, Double-Stranded RNA, and Viruses
  • Structure and Function of the Protein Kinase R
  • Virus Defense
  • Viral Regulation and Evasion of the Host Response
  • Pathogenic Viruses: Smart Manipulators of the Interferon System
  • Role of Interferon in Viral Infection and Autoimmunity
  • Type I Interferon During Viral Infections: Multiple Triggers for a Multifunctional Mediator
  • Type I Interferon in Systemic Lupus Erythematosus.