T Cell Activation by CD1 and Lipid Antigens

For decades, T cells were thought to solely respond to protein-derived antigens. However, the discovery of the CD1 antigen presenting system shows how antigen presenting cells can display lipid antigens to T cells. Crystal structures show that CD1 proteins accomplish this function by inserting lipid...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Moody, Branch D. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2007.
Edición:1st ed. 2007.
Colección:Current Topics in Microbiology and Immunology, 314
Temas:
Immunology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Molecular Biology
  • Evolutionary Biology of CD1
  • Architecture of CD1 Proteins
  • Structure and Biology of Self Lipid Antigens
  • Structures and Functions of Microbial Lipid Antigens Presented by CD1
  • Cellular Biology
  • CD1 Expression on Antigen-Presenting Cells
  • Pathways of CD1 and Lipid Antigen Delivery, Trafficking, Processing, Loading, and Presentation
  • TCR-Mediated Recognition of Glycolipid CD1 Complexes
  • Development and Selection of V?14i NKT Cells
  • Disease
  • CD1-Restricted T Cells in Host Defense to Infectious Diseases
  • NKT Cells and Autoimmune Diseases: Unraveling the Complexity
  • iNKT Cells in Allergic Disease
  • CD1-Restricted T Cells and Tumor Immunity
  • Harnessing NKT Cells for Therapeutic Applications.

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