Tubulin-Binding Agents Synthetic, Structural and Mechanistic Insights /

reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year pe...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Carlomagno, Teresa (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2009.
Edición:1st ed. 2009.
Colección:Topics in Current Chemistry, 286
Temas:
Medicinal chemistry.
Biochemistry.
Cancer.
Chemistry, Organic.
Analytical chemistry.
Medicinal Chemistry.
Cancer Biology.
Organic Chemistry.
Analytical Chemistry.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Macrolide-Based Microtubule-Stabilizing Agents - Chemistry and Structure-Activity Relationships
  • The Chemical Synthesis of Discodermolide
  • The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels
  • The Tubulin Binding Mode of MT Stabilizing and Destabilizing Agents Studied by NMR
  • The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography
  • Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin
  • Molecular Modeling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents.

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