Distribution and Phenotype of Proliferating Cells in the Forebrain of Adult Macaque Monkeys after Transient Global Cerebral Ischemia

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Tonchev, A.B (Autor), Yamashima, T. (Autor), Chaldakov, G.N (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2007.
Edición:1st ed. 2007.
Colección:Advances in Anatomy, Embryology and Cell Biology, 191
Temas:
Neurosciences.
Neuroscience.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • 1 Introduction.-.1 Studies on cell proliferation in adult primate brain
  • 1.2 Methodological considerations in detecting cell proliferation
  • 1.3 Cell proliferation in rodent brain after ischemia
  • 1.4 Global cerebral ischemia in primates
  • 2 Materials and Methods
  • 2.1 Animal subjects
  • 2.2 Bromodeoxyuridine infusion protocol
  • 2.3 Tissue processing
  • 2.4 Immunohistochemistry
  • 2.5 Detection of DNA damage and degenerating cells
  • 2.6 Electron microscopy
  • 2.7 Image acquisition and analysis
  • 2.8 Statistical analysis
  • 3 Results
  • 3.1 Hippocampal formation
  • 3.1.1 Dentate gyrus
  • 3.1.2 Cornu Ammonis
  • 3.1.3 Subiculum
  • 3.2 Subventricular zone of the inferior horn of the lateral ventricle (SVZi)
  • 3.3 Temporal lobe
  • 3.3.1 Parahippocampal region
  • 3.3.2 Temporal neocortex
  • 3.4 Subventricular zone of the anterior horn of the lateral ventricle (SVZa)
  • 3.5 Rostral migratory stream and olfactory bulb
  • 3.6 Frontal neocortex and striatum
  • 4 Discussion
  • 4.1 BrdU as a proliferation marker
  • 4.2 Effects of ischemia on cell proliferation and differentiation
  • 4.3 Sustained progenitor cell existence in germinative zones
  • 4.4 Implications of monkey findings for therapies in humans
  • 5 Summary
  • References
  • Subject Index.

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