Alternative Splicing and Disease

Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Jeanteur, Philippe (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2006.
Edición:1st ed. 2006.
Colección:Progress in Molecular and Subcellular Biology, 44
Temas:
Cytology.
Medicine > Research.
Biology > Research.
Biochemistry.
Cell Biology.
Biomedical Research.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Methods and Platforms for the Quantification of Splice Variants' Expression
  • Pre-mRNA Missplicing as a Cause of Human Disease
  • Alternative Splicing: Therapeutic Target and Tool
  • SR Proteins as Potential Targets for Therapy
  • Misregulation of Tau Alternative Splicing in Neurodegeneration and Dementia
  • Spinal Muscular Atrophy and Therapeutic Prospects
  • Misregulation of Alternative Splicing Causes Pathogenesis in Myotonic Dystrophy
  • Redirecting Splicing to Address Dystrophin Mutations: Molecular By-pass Surgery
  • Altered Splicing in Prelamin A-Associated Premature Aging Phenotypes
  • Splicing Modulation as a Modifier of the CFTR Function.

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