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Free-Radical-Induced DNA Damage and Its Repair A Chemical Perspective /
Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals hav...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Autor Corporativo: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2006.
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| Edición: | 1st ed. 2006. |
| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
| LEADER | 00000nam a22000005i 4500 | ||
|---|---|---|---|
| 001 | 978-3-540-30592-7 | ||
| 003 | DE-He213 | ||
| 005 | 20220114083106.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 100301s2006 gw | s |||| 0|eng d | ||
| 020 | |a 9783540305927 |9 978-3-540-30592-7 | ||
| 024 | 7 | |a 10.1007/3-540-30592-0 |2 doi | |
| 050 | 4 | |a QD415-436 | |
| 072 | 7 | |a PSB |2 bicssc | |
| 072 | 7 | |a SCI007000 |2 bisacsh | |
| 072 | 7 | |a PSB |2 thema | |
| 082 | 0 | 4 | |a 572 |2 23 |
| 100 | 1 | |a Sonntag, Clemens. |e author. |4 aut |4 http://id.loc.gov/vocabulary/relators/aut | |
| 245 | 1 | 0 | |a Free-Radical-Induced DNA Damage and Its Repair |h [electronic resource] : |b A Chemical Perspective / |c by Clemens Sonntag. |
| 250 | |a 1st ed. 2006. | ||
| 264 | 1 | |a Berlin, Heidelberg : |b Springer Berlin Heidelberg : |b Imprint: Springer, |c 2006. | |
| 300 | |a XX, 523 p. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 505 | 0 | |a Formation of Reactive Free Radicals in an Aqueous Environment -- The Hydroxyl Radical -- Hydrogen Atom and Hydrated Electron -- Inorganic Radicals -- Carbon-Centered Radicals -- Heteroatom-Centered Radicals -- Peroxyl Radicals -- Polymer Radicals -- Nucleobases, Nucleosides and Nucleotides -- Polynucleotides and Single-Stranded DNA Fragments -- DNA and Double-Stranded Oligonucleotides -- Methods. | |
| 520 | |a Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters. | ||
| 650 | 0 | |a Biochemistry. | |
| 650 | 0 | |a Cytology. | |
| 650 | 0 | |a Life sciences. | |
| 650 | 0 | |a Medicine-Research. | |
| 650 | 0 | |a Biology-Research. | |
| 650 | 0 | |a Oncology. | |
| 650 | 0 | |a Chemistry, Organic. | |
| 650 | 1 | 4 | |a Biochemistry. |
| 650 | 2 | 4 | |a Cell Biology. |
| 650 | 2 | 4 | |a Life Sciences. |
| 650 | 2 | 4 | |a Biomedical Research. |
| 650 | 2 | 4 | |a Oncology. |
| 650 | 2 | 4 | |a Organic Chemistry. |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9783540811398 |
| 776 | 0 | 8 | |i Printed edition: |z 9783642065545 |
| 776 | 0 | 8 | |i Printed edition: |z 9783540261209 |
| 856 | 4 | 0 | |u https://doi.uam.elogim.com/10.1007/3-540-30592-0 |z Texto Completo |
| 912 | |a ZDB-2-SBL | ||
| 912 | |a ZDB-2-SXB | ||
| 950 | |a Biomedical and Life Sciences (SpringerNature-11642) | ||
| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||