Axonal Branching and Recovery of Coordinated Muscle Activity after Transsection of the Facial Nerve in Adult Rats

Facial nerve surgery inevitably leads to partial pareses, abnormally associated movements and pathologically altered reflexes. The reason for this "post-paralytic syndrome" is the misdirected reinnervation of targets, which consists of two major components. First, due to malfunctioning axo...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Angelov, Doychin N. (Autor), Guntinas-Lichius, Orlando (Autor), Wewetzer, Konstantin (Autor), Neiss, Wolfram (Autor), Streppel, Michael (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2005.
Edición:1st ed. 2005.
Colección:Advances in Anatomy, Embryology and Cell Biology, 180
Temas:
Neurosciences.
Neuroscience.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Outline of the General Neurobiological Problem
  • The Perikarya Which Support Axonal Regrowth are Hyperexcitable
  • Axonal Regrowth is Compromised by Ephaptic Cross-Talk Between the Branches
  • Biological Significance of Axonal Branching
  • Role of Cytoskeleton Reorganization During Axonal Branching
  • The Individual Guidance Cues Promoting Reinnervation of Original Targets are Still Unknown
  • Conclusion
  • Outline of the Clinical Problem
  • Questions Still Open
  • Methodological Approach
  • Materials and Methods
  • First Set of Experiments: Attempts to Reduce Collateral Axonal Branching by Alterations of the Trigeminal Input to the Facial Perikarya
  • Second Set of Experiments: Attempts to Reduce Collateral Axonal Branching at the Lesion Site
  • Results
  • First Set of Experiments: Influence of the Altered Afferent Input to Axotomized Facial Perikarya on the Quality of Reinnervation
  • Second set of Experiments: Attempts to Reduce Collateral Axonal Branching at the Lesion Site
  • Discussion
  • The Combined Approach to Evaluate the Quality of Peripheral Nerve Regeneration
  • Sensory-Motor Integrity as A Factor for Motor Regeneration
  • Collateral Branching Versus Terminal Sprouting of Axons
  • Prospects for the Future
  • References
  • Subject index.

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