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Biocombinatorial Approaches for Drug Finding
Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds, particularly based on natural compounds, as screening resource. The purpose of the Ernst Schering Research Found...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2005.
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| Edición: | 1st ed. 2005. |
| Colección: | Ernst Schering Foundation Symposium Proceedings ;
51 |
| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- Protein Domain Fold Similarity and Natural Product Structure as Guiding Principles for Compound Library Design
- Sources of Polyketides and Non-Ribosomal Peptides
- Polyketide Synthases: Mechanisms and Models
- Functional and Structural Basis for Targeted Modification of Non-Ribosomal Peptlde Synthetases
- Prerequisites for Combinatorial Biosynthesis: Evolution of Hybrid NRPS/PKS Gene Clusters
- Engineering Glycosylation in Bioactive Compounds by Combinatorial Biosynthesis
- Glycosyltransferases and Other Tailoring Enzymes as Tools for the Generation of Novel Compounds
- Enzymatic Incorporation of Halogen Atoms into Natural Compounds
- From Glucose to Antibiotics: What Controls the Fluxes?
- Precursor-Directed Biosynthesis for the Generation of Novel Glycopetides
- Tool-Box: Tailoring Enzymes for Bio-Combinatorial Lead Development and as Markers for Genome-Based Natural Product Lead Discovery
- Natural Product Biosynthetic Assembly Lines: Prospects and Challenges for Reprogramming.