Structural Bioinformatics Tools for Drug Design Extraction of Biologically Relevant Information from Structural Databases /

A large amount of structural data on biomacromolecules is available and the number of resolved structures is growing rapidly. This implies that we have an increasing opportunity to perform so far unprecedented analyses to obtain crucial biological insight. Biomacromolecular structural fragments such...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Koča, Jaroslav (Autor), Svobodová Vařeková, Radka (Autor), Pravda, Lukáš (Autor), Berka, Karel (Autor), Geidl, Stanislav (Autor), Sehnal, David (Autor), Otyepka, Michal (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cham : Springer International Publishing : Imprint: Springer, 2016.
Edición:1st ed. 2016.
Colección:SpringerBriefs in Biochemistry and Molecular Biology,
Temas:
Biotechnology.
Bioinformatics.
Computational and Systems Biology.
Acceso en línea:Texto Completo

MARC

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100 1 |a Koča, Jaroslav.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
245 1 0 |a Structural Bioinformatics Tools for Drug Design  |h [electronic resource] :  |b Extraction of Biologically Relevant Information from Structural Databases /  |c by Jaroslav Koča, Radka Svobodová Vařeková, Lukáš Pravda, Karel Berka, Stanislav Geidl, David Sehnal, Michal Otyepka. 
250 |a 1st ed. 2016. 
264 1 |a Cham :  |b Springer International Publishing :  |b Imprint: Springer,  |c 2016. 
300 |a XIII, 144 p. 62 illus.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
490 1 |a SpringerBriefs in Biochemistry and Molecular Biology,  |x 2211-9361 
505 0 |a 1. Introduction -- 2. Biomacromolecular fragments -- 3. Databases -- 4. Detection & Extraction -- a. Biomacromolecular fragments and structural patterns -- b. channels and pores -- 5. Validation -- 6. Characterization -- a. Partial atomic charges -- b. Channel characteristics -- 7. Selected Examples. 
520 |a A large amount of structural data on biomacromolecules is available and the number of resolved structures is growing rapidly. This implies that we have an increasing opportunity to perform so far unprecedented analyses to obtain crucial biological insight. Biomacromolecular structural fragments such as binding sites or active sites, ligands, channels, pores, secondary structure motifs, etc., become very promising objects for these analyses because such fragments often serve as drug targets or drug templates, or substrate-specific pathways. However, such analyses are very challenging due to their complexity and, consequently, also because they require application of a combination of different software tools. In this book, we describe individual steps necessary for analysis of biomacromolecular fragments and provide a lsit of software tools required to perform such steps. For each step, we also show corresponding web-based tools in detail and provide a few practical examples of their usage. 
650 0 |a Biotechnology. 
650 0 |a Bioinformatics. 
650 1 4 |a Biotechnology. 
650 2 4 |a Bioinformatics. 
650 2 4 |a Computational and Systems Biology. 
700 1 |a Svobodová Vařeková, Radka.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
700 1 |a Pravda, Lukáš.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
700 1 |a Berka, Karel.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
700 1 |a Geidl, Stanislav.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
700 1 |a Sehnal, David.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
700 1 |a Otyepka, Michal.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer Nature eBook 
776 0 8 |i Printed edition:  |z 9783319473871 
776 0 8 |i Printed edition:  |z 9783319473895 
830 0 |a SpringerBriefs in Biochemistry and Molecular Biology,  |x 2211-9361 
856 4 0 |u https://doi.uam.elogim.com/10.1007/978-3-319-47388-8  |z Texto Completo 
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912 |a ZDB-2-SXB 
950 |a Biomedical and Life Sciences (SpringerNature-11642) 
950 |a Biomedical and Life Sciences (R0) (SpringerNature-43708) 

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