Disordered Vertebral and Rib Morphology in Pudgy Mice Structural Relationships to Human Congenital Scoliosis /

This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral a...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Shapiro, Frederic (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cham : Springer International Publishing : Imprint: Springer, 2016.
Edición:1st ed. 2016.
Colección:Advances in Anatomy, Embryology and Cell Biology, 221
Temas:
Medical genetics.
Anatomy, Comparative.
Biology > Technique.
Medical Genetics.
Animal Anatomy.
Experimental Organisms.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • I. INTRODUCTION
  • II. MATERIALS AND METHODS
  • 1. Source, distribution, and ages of pudgy and non-affected mice. - 2. Whole mount preparations
  • 3. Radiographic studies
  • 4. Histologic studies
  • 5. Computerized three-dimensional reconstructions
  • 6. Previous studies on chick vertebral development and human congenital scoliosis
  • III. RESULTS
  • 1. Gross appearance
  • 2. Whole mount appearances
  • 3. Radiographic studies
  • 4. Histology studies: vertebrae, ribs, intervertebral discs and ganglia
  • 5. Computerized three-dimensional reconstructions
  • 6. Chick embryo vertebral development
  • 7. Radiology and histopathology of human congenital scoliosis spine
  • IV. DISCUSSION
  • ion
  • 3. The pudgy mouse
  • 4. Genetic influences on axial development; mutations identified in mouse models with vertebral deformation
  • 5. Congenital scoliosis (human); its similarity with pudgy mouse vertebral abnormalities
  • 6. Pathogenesis of pudgy and human congenital scoliosis based on histopathologic studies.-V. CONCLUSIONS
  • 1. Implications of pudgy vertebral abnormalities for biologic research
  • 2. Implications of pudgy vertebral abnormalities for clinical patient treatment. .

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