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Translating Molecular Biomarkers into Clinical Assays Techniques and Applications /
This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated...
| Clasificación: | Libro Electrónico |
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| Autor Corporativo: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cham :
Springer International Publishing : Imprint: Springer,
2016.
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| Edición: | 1st ed. 2016. |
| Colección: | AAPS Advances in the Pharmaceutical Sciences Series,
21 |
| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- Foreword
- Fit-For-Purpose Validation
- Biomarkers in Drug Discovery and Development: Pre-Analytical and Analytical Considerations
- Biomarker Discovery
- Application of Quantitative Biomeasures in Early Drug Discovery
- Biomarkers in discovery and preclinical phase during drug development
- Incorporating clinical biomarkers into clinical trials
- Perspectives on Tissue Biobanking for Personalized Medicine
- The role of commercial biomarker assay kits in preclinical and clinical trials kits
- Quantification of protein biomarkers using liquid chromatography tandem mass spectrometry
- LC/MS methods for small Molecule biomarkers
- Cell-based Assays
- New Technologies for Cellular Analysis
- Flow cytometry methods for the Clinical Development of Immunomodulatory Biologics
- Key mass spectrometry techniques used in clinical biomarker research
- Clinical Genomic Biomarker Assay Development: Technologies and Issues
- Implementation of Immunohistochemistry assays for clinical trial sample analyses
- Strategic Approach to Outsourcing Clinical Biomarker Assays through CRO Relationships
- In situ hybridization (ISH) in Clinical Biomarker Development. .