Cargando…

Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules

This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction st...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Sharpe, Robert.J (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cham : Springer International Publishing : Imprint: Springer, 2016.
Edición:1st ed. 2016.
Colección:Springer Theses, Recognizing Outstanding Ph.D. Research,
Temas:
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Asymmetric Synthesis Of The Aminocyclitol Pactamycin, A Universal Translocation Inhibitor
  • Preparation And Biological Evaluation Of Synthetic and Polymer-Encapsulated Congeners of the Antitumor Agent Pactamycin: Insight Into Functional Group Effects and Biological Activity
  • Inception and Development of a Global and Local Desymmetrization Approach to the Synthesis of Steroidal Alkaloids: Stereocontrolled Total Synthesis of Paspaline.