Group Sequential and Confirmatory Adaptive Designs in Clinical Trials

This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs. Confirmatory adaptive designs are a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop the trial prematurely under contr...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Wassmer, Gernot (Autor), Brannath, Werner (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cham : Springer International Publishing : Imprint: Springer, 2016.
Edición:1st ed. 2016.
Colección:Springer Series in Pharmaceutical Statistics,
Temas:
Biometry.
Pharmacovigilance.
Pharmaceutical chemistry.
Biostatistics.
Drug Safety and Pharmacovigilance.
Pharmaceutics.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Part I Group Sequential Designs
  • Repeated Significance Tests: Procedures with Equally Sized Stages
  • Procedures with Unequally Sized Stages
  • Confidence Intervals, p -Values, and Point Estimation
  • Applications
  • Part II Adaptive Confirmatory Designs with a Single Hypothesis: Adaptive Group Sequential Tests
  • Decision Tools for Adaptive Designs
  • Estimation and p-Values for Two-stage Adaptive Designs
  • Adaptive Designs with Survival Data
  • Part III Adaptive Designs with Multiple Hypotheses: Multiple Testing in Adaptive Designs
  • Applications and Case Studies
  • Appendix - Software for Adaptive Designs
  • Index.

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