Physics at the Biomolecular Interface Fundamentals for Molecular Targeted Therapy /

This book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophy...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Fernández, Ariel (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cham : Springer International Publishing : Imprint: Springer, 2016.
Edición:1st ed. 2016.
Colección:Soft and Biological Matter,
Temas:
Biophysics.
Physical chemistry.
Pharmaceutical chemistry.
Proteins.
Medicine-Research.
Biology-Research.
System theory.
Physical Chemistry.
Pharmaceutics.
Biomedical Research.
Complex Systems.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Chapter 1 Interfacial Physics for Water in Biology
  • Chapter 2 Dielectric Structure of Aqueous Interfaces: From Classical non-Debye Electrostatics to a Quantum Theory of Interfacial Tension
  • Chapter 3 Solution to the Protein Folding Problem
  • Chapter 4 Epistructural Dynamics of Biological Water
  • Chapter 5 Dehydron-Rich Proteins in the Order-Disorder Twilight Zone
  • Chapter 6 Dehydron as a Marker for Molecular Evolution: Lessons for the Drug Designer
  • Chapter 7 Catalytic Role of Dehydrons in Soluble Proteins: Biological Chemistry of Frustrated Interfacial Water
  • Chapter 8 Epistructural Selectivity Filters for Molecular Targeted Therapy
  • Chapter 9 Epistructural Re-Engineering ofImatinib to Eliminate Adverse Side Effects
  • Chapter 10 Epistructural Informatics for the Drug Designer
  • Chapter 11 Drug-Target Associations Inducing Protein Folding
  • Chapter 12 Combination Therapies to Edit Out Side Effects and Resistance to Inhibition of Drug Resistance
  • Chapter 13 Epistructure-Based Design of Drugs with Controlled Promiscuity
  • Chapter 14 Synergizing Engineered Immunotherapy with Molecularly Targeted Cancer Treatment
  • Chapter 15 Quantum Mechanical Concepts for Epistructural Drug Design
  • Chapter 16 Structure-Based Drug Discovery Without Structure: Working Around the Paradox to Disrupt Protein-Protein Associations
  • Chapter 17 Epistructural Drug Design to Treat Cancer Metastasis and the Associated Drug Resistance.

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