Cargando…

Alpha-1 Antitrypsin Role in Health and Disease /

This book offers a comprehensive overview of alpha-1 antitrypsin deficiency, an inherited condition that leads to lung disease in adults and liver disease in adults and children. While it is a rare condition, the mechanisms underlying its clinical manifestations have been largely clarified. Specific...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Wanner, Adam (Editor ), Sandhaus, Robert A. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cham : Springer International Publishing : Imprint: Humana, 2016.
Edición:1st ed. 2016.
Colección:Respiratory Medicine,
Temas:
Acceso en línea:Texto Completo

MARC

LEADER 00000nam a22000005i 4500
001 978-3-319-23449-6
003 DE-He213
005 20220108072520.0
007 cr nn 008mamaa
008 151218s2016 sz | s |||| 0|eng d
020 |a 9783319234496  |9 978-3-319-23449-6 
024 7 |a 10.1007/978-3-319-23449-6  |2 doi 
050 4 |a RC705-779 
072 7 |a MJL  |2 bicssc 
072 7 |a MED079000  |2 bisacsh 
072 7 |a MJL  |2 thema 
082 0 4 |a 616.2  |2 23 
245 1 0 |a Alpha-1 Antitrypsin  |h [electronic resource] :  |b Role in Health and Disease /  |c edited by Adam Wanner, Robert A. Sandhaus. 
250 |a 1st ed. 2016. 
264 1 |a Cham :  |b Springer International Publishing :  |b Imprint: Humana,  |c 2016. 
300 |a X, 173 p. 27 illus., 12 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
490 1 |a Respiratory Medicine,  |x 2197-7380 
505 0 |a Alpha-1- Antitrypsin and the Serpins -- Alpha-1 Antitrypsin: The protein -- Misfolding and Polymerisation of Alpha1-Antitrypsin - Conformational Pathology and Therapeutic Targeting -- Managing the Adaptive Proteostatic Landscape: Restoring Resilience in Alpha-1 Antitrypsin Deficiency -- United States Targeted Detection Program for Alpha-1 Antitrypsin Deficiency -- Lung Disease of Alpha-1 Antitrypsin Deficiency -- Alpha-1-Antitrypsin Deficiency: Role in Health and Disease -- Alpha-1 Antitrypsin as a Therapeutic Agents for Conditions not Associated with Alpha-1 Antitrypsin Deficiency -- The Alpha-1 Constellation of Voluntary Health Organizations as a Paradigm for Confronting Other Rare Diseases. 
520 |a This book offers a comprehensive overview of alpha-1 antitrypsin deficiency, an inherited condition that leads to lung disease in adults and liver disease in adults and children. While it is a rare condition, the mechanisms underlying its clinical manifestations have been largely clarified. Specific treatment, however, is available only for the lung disease that arises from the condition, thus necessitating continued research into new and alternative therapeutic solutions. The book discusses the biology of alpha-1 antitrypsin, protein misfolding and polymerization, and diagnosis and treatment of alpha-1 antitrypsin deficiency and its associated diseases.  It concludes with a discussion of  alpha-1 antitrypsin therapy in diseases not associated with alpha-1 antitrypsin deficiency, and the role of healthcare organizations in the rare disease space. Written for pulmonary clinicians and scientists, Alpha-1 Antitrypsin: Role in Health and Disease is a valuable resource that sheds light on this rare disease. . 
650 0 |a Respiratory organs-Diseases. 
650 1 4 |a Pneumology. 
700 1 |a Wanner, Adam.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
700 1 |a Sandhaus, Robert A.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer Nature eBook 
776 0 8 |i Printed edition:  |z 9783319234489 
776 0 8 |i Printed edition:  |z 9783319234502 
776 0 8 |i Printed edition:  |z 9783319794846 
830 0 |a Respiratory Medicine,  |x 2197-7380 
856 4 0 |u https://doi.uam.elogim.com/10.1007/978-3-319-23449-6  |z Texto Completo 
912 |a ZDB-2-SME 
912 |a ZDB-2-SXM 
950 |a Medicine (SpringerNature-11650) 
950 |a Medicine (R0) (SpringerNature-43714)