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Biomolecular Interfaces Interactions, Functions and Drug Design /
The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that h...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Autor Corporativo: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cham :
Springer International Publishing : Imprint: Springer,
2015.
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| Edición: | 1st ed. 2015. |
| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology
- Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water
- Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches
- Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface
- Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation
- Evolution of Protein Structure Degradation and Lessons for the Drug Designer
- Chemical Functionality of the Aqueous Interface in Soluble Proteins
- The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy
- Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer
- Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine
- Controlling Induced Folding Through Wrapping Drug Design
- Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology
- Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology
- Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment
- High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design
- Epilogue
- Appendix 1. Code for Dehydron Identification
- Appendix 2. Solutions of Problems.