Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450

This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mec...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Hrycay, Eugene G. (Editor ), Bandiera, Stelvio M. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cham : Springer International Publishing : Imprint: Springer, 2015.
Edición:1st ed. 2015.
Colección:Advances in Experimental Medicine and Biology, 851
Temas:
Medicine-Research.
Biology-Research.
Biomedical Research.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Foreword
  • 1. Monooxygenase, Peroxidase and Peroxygenase Properties and Reaction Mechanisms of Cytochrome P450 Enzymes
  • 2. Oxidizing Intermediates in P450 Catalysis: A Case for Multiple Oxidants
  • 3. Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions
  • 4. Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1
  • 5. Regioselective Versatility of Monooxygenase Reactions Catalyzed by CYP2B6 and CYP3A4: Examples With Single Substrates
  • 6. Cytochrome P450 Enzymes in the Bioactivation of Polyunsaturated Fatty Acids and their Role in Cardiovascular Disease
  • 7. Monooxygenation of Small Hydrocarbons Catalyzed by Bacterial Cytochrome P450s
  • 8. Use of Chemical Auxiliaries to Control P450 Enzymes for Predictable Oxidations at Unactivated C-H Bonds of Substrates,- 9. Cytochrome P450 Enzymes and Electrochemistry: Crosstalk with Electrodes as Redox Partners and Electron Sources
  • 10. Mechanistic Basis of Electron Transfer to Cytochromes P450 by Natural Redox Partners and Artificial Donor Constructs
  • 11. Biological Diversity of Cytochrome P450 Redox Partner Proteins
  • 12. Cytochrome P450cin (CYP176A1)
  • 13. Fungal Unspecific Peroxygenases: Heme-Thiolate Proteins that Combine Peroxidase and Cytochrome P450 Properties.

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