Protein Kinase CK2 Cellular Function in Normal and Disease States

The field of protein kinases has greatly impacted our understanding of the basic mechanisms in cell function. The field has also been a major focus of drug development that considers the broad reach of the protein kinase function under diverse conditions. One member of the kinome, protein kinase CK2...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Ahmed, Khalil (Editor ), Issinger, Olaf-Georg (Editor ), Szyszka, Ryszard (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cham : Springer International Publishing : Imprint: Springer, 2015.
Edición:1st ed. 2015.
Colección:Advances in Biochemistry in Health and Disease, 12
Temas:
Cancer.
Proteins .
Cell death.
Cancer Biology.
Protein Biochemistry.
Cell Death.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • 1. CK2 Suppression of Apoptosis
  • 2. Structural Determinants of CK2 Regulation
  • 3. Targeting Protein Kinase: CK2 Suppresses Pro-Survival Signaling Pathways and Growth of Gliobastoma
  • 4. The Roles of CK2 in Drosophila Neurogenesis
  • 5. Targeting the CK2 Subunit Interface: Challenge and Usefulness
  • 6. CK2 in Wnt/β-catenin signaling and embryo development
  • 7. Defective expression of CK2β promotes EMT and stemness properties both required for breast cancer progression
  • 8. Chemical Biology Approaches to Identify CK2 Substrates and Perform Unbiased Evaluation of CK2 Inhibitors
  • 9. Development of Screening Systems and Identification of Novel Potent Inhibitors of Human Protein Kinase CK2
  • 10. Protein Kinase CK2: At the Crossroad of Regulatory Cellular Pathways
  • 11. Functional Regulation of DYRK Family Protein Kinases by Cellular Binding Partners
  • 12. Regulation of CK2 in pancreatic β cells
  • 13. Recent impressions from the configurational and conformational space captured by protein kinase CK2
  • 14. Role of CK2 in Plant Responses to Abiotic Stress
  • 15. "Genuine" Casein Kinase: The False Sister of CK2: Phosphorylates-Secreted Proteins
  • 16. CK2: - A Novel Player in L-DOPA induced dyskinesia in a mouse model of Parkinson's disease
  • 17. CK2 function in the regulation of Akt Pathway: new findings and perspectives
  • 18. CK2 structure from yeast to human
  • 19. Cellular zinc signaling is triggered by CK2
  • 20. A Nanomedicine Approach to Targeting CK2 for Cancer therapy
  • 21. Bisubstrate approach for construction of high-affinity inhibitors and optical probes for protein kinase CK2.

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