ADAMTS13 Biology and Disease /

This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its no...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Rodgers, George M. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cham : Springer International Publishing : Imprint: Springer, 2015.
Edición:1st ed. 2015.
Temas:
Proteins .
Hematology.
Cytology.
Protein Biochemistry.
Cell Biology.
Acceso en línea:Texto Completo

MARC

LEADER 00000nam a22000005i 4500
001 978-3-319-08717-7
003 DE-He213
005 20220119014826.0
007 cr nn 008mamaa
008 150813s2015 sz | s |||| 0|eng d
020 |a 9783319087177  |9 978-3-319-08717-7 
024 7 |a 10.1007/978-3-319-08717-7  |2 doi 
050 4 |a QD431-431.7 
072 7 |a PSBC  |2 bicssc 
072 7 |a SCI007000  |2 bisacsh 
072 7 |a PSB  |2 thema 
082 0 4 |a 572.6  |2 23 
245 1 0 |a ADAMTS13  |h [electronic resource] :  |b Biology and Disease /  |c edited by George M. Rodgers. 
250 |a 1st ed. 2015. 
264 1 |a Cham :  |b Springer International Publishing :  |b Imprint: Springer,  |c 2015. 
300 |a X, 186 p. 33 illus., 24 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
505 0 |a 1. A13: Structure and function -- 2. A13: The von Willebrand factor cleaving protease -- 3. A13: Angiogenesis and other biologic activities -- 4. A13:  Assays -- 5. Inherited A13 deficiency (Upshaw-Schulman Syndrome) -- 6. Acquired A13 deficiency (TTP) -- 7. Related thrombotic microangiopathies -- 8. Future directions. 
520 |a This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility.   Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases. 
650 0 |a Proteins . 
650 0 |a Hematology. 
650 0 |a Cytology. 
650 1 4 |a Protein Biochemistry. 
650 2 4 |a Hematology. 
650 2 4 |a Cell Biology. 
700 1 |a Rodgers, George M.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer Nature eBook 
776 0 8 |i Printed edition:  |z 9783319087160 
776 0 8 |i Printed edition:  |z 9783319087184 
776 0 8 |i Printed edition:  |z 9783319347301 
856 4 0 |u https://doi.uam.elogim.com/10.1007/978-3-319-08717-7  |z Texto Completo 
912 |a ZDB-2-SBL 
912 |a ZDB-2-SXB 
950 |a Biomedical and Life Sciences (SpringerNature-11642) 
950 |a Biomedical and Life Sciences (R0) (SpringerNature-43708) 

Ejemplares similares