Modelling the Short QT Syndrome Gene Mutations And Their Role in Cardiac Arrhythmogenesis /

The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not com...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Adeniran, Ismail (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cham : Springer International Publishing : Imprint: Springer, 2014.
Edición:1st ed. 2014.
Colección:Springer Theses, Recognizing Outstanding Ph.D. Research,
Temas:
Bioinformatics.
Biological transport.
Cell membranes.
System theory.
Cardiology.
Mathematical physics.
Computational and Systems Biology.
Membrane Trafficking.
Complex Systems.
Theoretical, Mathematical and Computational Physics.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Ion Channels and the Action Potential
  • Potassium Channels Implicated in the Short QT Syndrome
  • The Short QT Syndrome
  • Model Development
  • Methods, Experimental Protocols and Mathematical Preliminaries
  • Increased Vulnerability of the Human Ventricle to Re-entrant Excitation in HERG-linked SQT1
  • Mathematically Modelling the Functional Consequences of the SQT2 Mutation
  • Proarrhythmia in KCNJ2-linked Short QT Syndrome: Insights from Modelling
  • Relationship between Electrical and Mechanical Systole in the Short QT Syndrome: Insights from Modelling
  • Discussion and Conclusion.

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