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Modelling the Short QT Syndrome Gene Mutations And Their Role in Cardiac Arrhythmogenesis /
The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not com...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Autor Corporativo: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cham :
Springer International Publishing : Imprint: Springer,
2014.
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| Edición: | 1st ed. 2014. |
| Colección: | Springer Theses, Recognizing Outstanding Ph.D. Research,
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| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
| LEADER | 00000nam a22000005i 4500 | ||
|---|---|---|---|
| 001 | 978-3-319-07200-5 | ||
| 003 | DE-He213 | ||
| 005 | 20220118012852.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 140611s2014 sz | s |||| 0|eng d | ||
| 020 | |a 9783319072005 |9 978-3-319-07200-5 | ||
| 024 | 7 | |a 10.1007/978-3-319-07200-5 |2 doi | |
| 050 | 4 | |a QH324.2-324.25 | |
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| 082 | 0 | 4 | |a 570.113 |2 23 |
| 100 | 1 | |a Adeniran, Ismail. |e author. |4 aut |4 http://id.loc.gov/vocabulary/relators/aut | |
| 245 | 1 | 0 | |a Modelling the Short QT Syndrome Gene Mutations |h [electronic resource] : |b And Their Role in Cardiac Arrhythmogenesis / |c by Ismail Adeniran. |
| 250 | |a 1st ed. 2014. | ||
| 264 | 1 | |a Cham : |b Springer International Publishing : |b Imprint: Springer, |c 2014. | |
| 300 | |a XVII, 217 p. 102 illus., 38 illus. in color. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a Springer Theses, Recognizing Outstanding Ph.D. Research, |x 2190-5061 | |
| 505 | 0 | |a Ion Channels and the Action Potential -- Potassium Channels Implicated in the Short QT Syndrome -- The Short QT Syndrome -- Model Development -- Methods, Experimental Protocols and Mathematical Preliminaries -- Increased Vulnerability of the Human Ventricle to Re-entrant Excitation in HERG-linked SQT1 -- Mathematically Modelling the Functional Consequences of the SQT2 Mutation -- Proarrhythmia in KCNJ2-linked Short QT Syndrome: Insights from Modelling -- Relationship between Electrical and Mechanical Systole in the Short QT Syndrome: Insights from Modelling -- Discussion and Conclusion. | |
| 520 | |a The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases. The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as "outstanding.". | ||
| 650 | 0 | |a Bioinformatics. | |
| 650 | 0 | |a Biological transport. | |
| 650 | 0 | |a Cell membranes. | |
| 650 | 0 | |a System theory. | |
| 650 | 0 | |a Cardiology. | |
| 650 | 0 | |a Mathematical physics. | |
| 650 | 1 | 4 | |a Computational and Systems Biology. |
| 650 | 2 | 4 | |a Membrane Trafficking. |
| 650 | 2 | 4 | |a Complex Systems. |
| 650 | 2 | 4 | |a Cardiology. |
| 650 | 2 | 4 | |a Theoretical, Mathematical and Computational Physics. |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9783319072012 |
| 776 | 0 | 8 | |i Printed edition: |z 9783319071992 |
| 776 | 0 | 8 | |i Printed edition: |z 9783319361512 |
| 830 | 0 | |a Springer Theses, Recognizing Outstanding Ph.D. Research, |x 2190-5061 | |
| 856 | 4 | 0 | |u https://doi.uam.elogim.com/10.1007/978-3-319-07200-5 |z Texto Completo |
| 912 | |a ZDB-2-PHA | ||
| 912 | |a ZDB-2-SXP | ||
| 950 | |a Physics and Astronomy (SpringerNature-11651) | ||
| 950 | |a Physics and Astronomy (R0) (SpringerNature-43715) | ||