Gamma-Glutamyl Transpeptidases Structure and Function /

 Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptid...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Castellano, Immacolata (Autor), Merlino, Antonello (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Basel : Springer Basel : Imprint: Springer, 2013.
Edición:1st ed. 2013.
Colección:SpringerBriefs in Biochemistry and Molecular Biology,
Temas:
Enzymology.
Human physiology.
Biotechnology.
Human Physiology.
Chemical Bioengineering.
Acceso en línea:Texto Completo

MARC

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245 1 0 |a Gamma-Glutamyl Transpeptidases  |h [electronic resource] :  |b Structure and Function /  |c by Immacolata Castellano, Antonello Merlino. 
250 |a 1st ed. 2013. 
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300 |a VIII, 57 p. 28 illus., 18 illus. in color.  |b online resource. 
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505 0 |a  1 Introduction -- 2 Occurrence, genes and gene expression -- 3 Structure and function of γ-GTs -- 4 Autoprocessing and reaction mechanism of γ-GTs -- 5 γ-GT in bioclinical -- 6 γ-GTs: biotechnological and biomedical applications -- 7 Conclusions -- References. 
520 |a  Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson's disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine. 
650 0 |a Enzymology. 
650 0 |a Human physiology. 
650 0 |a Biotechnology. 
650 1 4 |a Enzymology. 
650 2 4 |a Human Physiology. 
650 2 4 |a Chemical Bioengineering. 
700 1 |a Merlino, Antonello.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer Nature eBook 
776 0 8 |i Printed edition:  |z 9783034806831 
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830 0 |a SpringerBriefs in Biochemistry and Molecular Biology,  |x 2211-9361 
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950 |a Biomedical and Life Sciences (SpringerNature-11642) 
950 |a Biomedical and Life Sciences (R0) (SpringerNature-43708) 

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