mTOR Inhibition for Cancer Therapy: Past, Present and Future

This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for t...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Mita, Monica (Editor ), Mita, Alain (Editor ), Rowinsky, Eric K. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Paris : Springer Paris : Imprint: Springer, 2016.
Edición:1st ed. 2016.
Temas:
Oncology.
Hematology.
Medicine-Research.
Biology-Research.
Biomedical Research.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Forward
  • Past
  • mTOR inhibitors: a little bit of history
  • Present
  • The mTOR pathway
  • The evolving role of mTOR inhibitors in renal cell carcinoma
  • The role of mTOR inhibitors in breast cancer
  • The role of mTOR inhibitors in neuroendocrine tumors
  • New indications of mTOR inhibitors in rare tumors
  • The role of mTOR inhibitors in the treatment of hematological malignancies
  • The clinical pharmacology and toxicity profile of rapalogs
  • Resistance to mTOR inhibitors
  • Rational combinations of mTOR inhibitors as anticancer strategies
  • Future
  • Predictive biomarkers of response to mTOR inhibitors
  • The potential future indication of rapamycin analogs for the treatment of other solid tumors
  • mTOR inhibition beyond rapalogs
  • mTOR, aging and cancer: the missing link?
  • New study design for mTOR inhibitors and other biological agents
  • Future directions for the development of mTOR inhibitors.

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