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|a 9781617798122
|9 978-1-61779-812-2
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|a 10.1007/978-1-61779-812-2
|2 doi
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|a 615
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|a Immunotoxicity, Immune Dysfunction, and Chronic Disease
|h [electronic resource] /
|c edited by Rodney R. Dietert, Robert W. Luebke.
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250 |
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|a 1st ed. 2012.
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264 |
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|a Totowa, NJ :
|b Humana Press :
|b Imprint: Humana,
|c 2012.
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300 |
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|a XVI, 452 p.
|b online resource.
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336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
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|a text file
|b PDF
|2 rda
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490 |
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|a Molecular and Integrative Toxicology,
|x 2168-4235
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|a Introduction to Immunotoxicity -- The Environment-Immune Route to Chronic Disease -- Asthma and Respiratory Allergies -- Cutaneous Allergies -- Food Allergies -- Factors Involved in Onset of Type1 Diabetes -- Rheumatoid Arthritis -- Environment, Immune Dysfunction and Systemic Lupus Erythematosus -- Multiple Sclerosis, Alzheimer's Disease and Inflammation: A Hypothetical View -- Immune Dysfunction in Autism Spectrum Disorders -- Atherosclerosis and Inflammatory Heart Disease -- Inflammatory Bowel Disease and Celiac Disease: Environmental Risks Factors and Consequences -- COPD and Other Inflammatory Diseases of the Lung: Focus on AhR signaling -- Environment, the Immune System, and Depression: An Integrative Review and Discussion of the Infection-Defense Hypothesis -- Cancer - Childhood Acute Leukemia -- Environmental Toxicants and Susceptibility to Infection -- Reducing the Prevalence of Immune-Based Chronic Disease.
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|a Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes,multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus. Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction. Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions. This volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students. .
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650 |
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|a Pharmacology.
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650 |
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|a Immunology.
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650 |
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|a Medicine-Research.
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|a Biology-Research.
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|a Pharmacology.
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650 |
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|a Immunology.
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650 |
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|a Biomedical Research.
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700 |
1 |
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|a Dietert, Rodney R.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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700 |
1 |
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|a Luebke, Robert W.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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710 |
2 |
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|a SpringerLink (Online service)
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773 |
0 |
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|t Springer Nature eBook
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776 |
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|i Printed edition:
|z 9781617798115
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776 |
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8 |
|i Printed edition:
|z 9781617798139
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776 |
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8 |
|i Printed edition:
|z 9781627039260
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830 |
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|a Molecular and Integrative Toxicology,
|x 2168-4235
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856 |
4 |
0 |
|u https://doi.uam.elogim.com/10.1007/978-1-61779-812-2
|z Texto Completo
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912 |
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|a ZDB-2-SBL
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912 |
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|a ZDB-2-SXB
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950 |
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|a Biomedical and Life Sciences (SpringerNature-11642)
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950 |
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|a Biomedical and Life Sciences (R0) (SpringerNature-43708)
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