Targeted Therapeutics in Melanoma

Melanoma is an increasingly important public health problem. Although the cause of most malignant melanomas - over-exposure to ultraviolet light - is well known, effective treatment has remained challenging. The past several years have been marked by extraordinary developments in melanoma treatment...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Gajewski, Thomas F. (Editor ), Hodi, F. Stephen (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Totowa, NJ : Humana Press : Imprint: Humana, 2012.
Edición:1st ed. 2012.
Colección:Current Clinical Oncology,
Temas:
Oncology.
Cancer.
Cancer Biology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Molecular targets and subtypes in melanoma
  • Melanoma genomics
  • Predictive biomarkers as a guide to future therapy selection in melanoma
  • KIT as a therapeutic target for melanoma
  • Targeted inhibition of B-Raf
  • The notch and B-catenin pathways
  • STAT3 and Src signaling in melanoma
  • Targeting the mTOR, PI3K and AKT pathways in melanoma
  • Targeting apoptotic pathways in melanoma
  • Anti-angiogenesis therapy in melanoma
  • Melanoma antigens recognized by T lymphocytes
  • Melanoma vaccines
  • Adoptive cell therapy for the treatment of metastatic melanoma
  • Anti-CTLA-4 monolonal antibodies
  • Anti-PD-1 and Anti-B7-H1/PD-L1 monoclonal antibodies
  • Treatment of melanoma with agonist immune co-stimulatory agents
  • Novel cytokines for immunotherapy of melanoma
  • Modulating the tumor microenvironment.

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