Protein Kinase C in Cancer Signaling and Therapy

Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980's with its identification as an effector of phorbol esters, natural products with tumor-promoting activity. Phorbol esters had long been of interest to the canc...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Kazanietz, Marcelo G. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Totowa, NJ : Humana Press : Imprint: Humana, 2010.
Edición:1st ed. 2010.
Colección:Current Cancer Research,
Temas:
Cancer.
Pharmacology.
Cancer Biology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Regulation of PKC Isozyme Function: From Genes to Biochemistry
  • Protein Kinase C in Cancer Signaling and Therapy: Introduction and Historical Perspective
  • Regulation of Conventional and Novel Protein Kinase C Isozymes by Phosphorylation and Lipids
  • Phorbol Esters and Diacylglycerol: The PKC Activators
  • Diacylglycerol Signaling: The C1 Domain, Generation of DAG, and Termination of Signals
  • Regulation of PKC by Protein-Protein Interactions in Cancer
  • PKC Isozymes in the Control of Cell Function
  • Introduction: PKC Isozymes in the Control of Cell Function
  • Regulation and Function of Protein Kinase D Signaling
  • PKC and Control of the Cell Cycle
  • PKC and the Control of Apoptosis
  • Atypical PKCs, NF-?B, and Inflammation
  • PKC Isozymes in Cancer
  • Introduction: PKC and Cancer
  • Protein Kinase C, p53, and DNA Damage
  • PKCs as Mediators of the Hedgehog and Wnt Signaling Pathways
  • PKC-PKD Interplay in Cancer
  • Transgenic Mouse Models to Investigate Functional Specificity of Protein Kinase C Isoforms in the Development of Squamous Cell Carcinoma, a Nonmelanoma Human Skin Cancer
  • PKC Isozymes and Skin Cancer
  • PKC and Breast Cancer
  • PKC and Prostate Cancer
  • Protein Kinase C and Lung Cancer
  • PKC Isozymes as Targets for Cancer Therapy
  • PKC and Resistance to Chemotherapeutic Agents
  • PKC? as a Target for Chemotherapeutic Drugs
  • Atypical PKCs as Targets for Cancer Therapy.

Ejemplares similares