Telomeres and Telomerase in Cancer

Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Hiyama, Keiko (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Totowa, NJ : Humana Press : Imprint: Humana, 2009.
Edición:1st ed. 2009.
Colección:Cancer Drug Discovery and Development,
Temas:
Cancer.
Oncology.
Pharmacology.
Cancer Biology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Basic Background
  • Telomeres and Telomerase in Humans
  • Telomere-Binding Proteins in Humans
  • Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms
  • Telomere Dysfunction and the DNA Damage Response
  • Alternative Lengthening of Telomeres in Human Cells
  • Mouse Model: Telomeres and Telomerase in Stem Cell and Cancer
  • Telomeres and Telomerase in Human Cancers
  • Role of Telomeres and Telomerase in Cancer
  • Diagnostic Value I: Solid Tumors
  • Diagnostic Value II: Hematopoietic Malignancies
  • Therapeutic Targets and Drugs I: Telomerase and Telomerase Inhibitors
  • Therapeutic Targets and Drugs II: G-Quadruplex and G-Quadruplex Inhibitors
  • Therapeutic Targets and Drugs III: Tankyrase 1, Telomere-Binding Proteins, and Inhibitors
  • Therapeutic Targets and Drugs IV: Telomerase-Specific Gene and Vector-Based Therapies for Human Cancer
  • Experimental Protocols
  • Protocol I: Telomerase Activity and Telomerase Expression
  • Protocol II: Importance and Methods of Telomere G-Tail Length Quantification
  • Protocol III: Detection of Alternative Lengthening of Telomeres.

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