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Functional Selectivity of G Protein-Coupled Receptor Ligands New Opportunities for Drug Discovery /
Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse p...
| Clasificación: | Libro Electrónico |
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| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2009.
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| Edición: | 1st ed. 2009. |
| Colección: | The Receptors,
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| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- Theoretical and Mechanistic Aspects of Functional Selectivity
- Historical Overview of the Concept of Functional Selectivity
- Functional Selectivity: Theoretical Considerations and Future Directions
- Agonist-Selective Coupling of G Protein-Coupled Receptors
- Ligand-Selective Receptor Desensitization and Endocytosis
- Selectivity for G Protein or Arrestin-Mediated Signaling
- In Vivo Evidence for and Consequences of Functional Selectivity
- Subfamilies of Therapeutically Relevant Receptors
- Functional Selectivity at Adrenergic Receptors
- Signaling Diversity Mediated by Muscarinic Acetylcholine Receptor Subtypes and Evidence for Functional Selectivity
- Functional Selectivity at Serotonin Receptors
- Functional Selectivity at Dopamine Receptors
- Functional Selectivity at Receptors for Cannabinoids and Other Lipids
- Functional Selectivity at Opioid Receptors
- Functional Selectivity at Non-Opioid Peptide Receptors.