mTOR Pathway and mTOR Inhibitors in Cancer Therapy

mTOR Pathway and mTOR Inhibitors in Cancer Therapy provides an up-to-date survey of the rapidly advancing field of cancer therapy. Our understanding of the mechanisms involved in cancer genesis and progression underwent unprecedented expansion during the last decade, opening a new era of cancer trea...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Polunovsky, Vitaly A. (Editor ), Houghton, Peter J. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Totowa, NJ : Humana Press : Imprint: Humana, 2010.
Edición:1st ed. 2010.
Colección:Cancer Drug Discovery and Development,
Temas:
Cancer.
Cytology.
Pharmacology.
Cancer Biology.
Cell Biology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • mTORC1: A Signaling Integration Node Involved in Cell Growth
  • The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions
  • mTOR Signaling in Angiogenesis
  • mTORC1 Signaling and Hypoxia
  • mTOR Signaling in Glioblastoma: Lessons Learned from Bench to Bedside
  • mTOR and Cancer Therapy: General Principles
  • mTOR and Cancer Therapy: Clinical Development and Novel Prospects
  • Drug Combinations as a Therapeutic Approach for mTORC1 Inhibitors in Human Cancer
  • Downstream Targets of mTORC1
  • Downstream of mTOR: Translational Control of Cancer
  • Genome-Wide Analysis of Translational Control
  • Translational Control of Cancer: Implications for Targeted Therapy
  • Downstream from mTOR: Therapeutic Approaches to Targeting the eIF4F Translation Initiation Complex.

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