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Regulation of Gene Expression

Regulation of Gene Expression: Molecular Mechanisms presents a comprehensive overview of methods and approaches for characterizing mechanisms of gene regulation. The text is appropriate both as a graduate textbook and a standard laboratory reference and provides the essential groundwork for an advan...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Perdew, Gary H. (Autor), Vanden Heuvel, Jack P. (Autor), Peters, Jeffrey M. (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Totowa, NJ : Humana Press : Imprint: Humana, 2007.
Edición:1st ed. 2007.
Temas:
Acceso en línea:Texto Completo

MARC

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505 0 |a Gene Expression Control At The Mrna Level -- Overview -- Messenger RNA Accumulation -- Transcript Profiling -- Transcriptional Regulation of Gene Expression -- Posttranscriptional Processing of Messenger RNA -- Regulation Of Protein Levels And Transcription Factor Function -- Overview -- Protein Synthesis and Turnover -- Proteomics -- Determination of Protein-Protein Interactions and the Motifs That Mediate Them -- Posttranslational Modifications -- Dissection of Signaling Pathways -- Use Of Transgenic And Knockout Mice To Study Gene Regulation -- Overview -- Production of Transgenic Animals -- Knockout Animals -- Isolation of Cells and Cell Lines From Transgenic and Knockout Animals. 
520 |a Regulation of Gene Expression: Molecular Mechanisms presents a comprehensive overview of methods and approaches for characterizing mechanisms of gene regulation. The text is appropriate both as a graduate textbook and a standard laboratory reference and provides the essential groundwork for an advanced understanding of the various mechanisms that may result in altered activity of a specific cell protein. Each of three sections explores mechanisms of gene regulation and expression, and presents methods and protocols for achieving specific experimental goals. Part I focuses on approaches for studying control of mRNA expression and determining target genes for a given transcription copy. Part II outlines the methods for determining how proteins can regulate each other by mediating synthesis, degradation, protein-protein interactions, and posttranslational modification. Part III explores how gene targeting techniques in mice can provide insight into protein function. This volume provides a clear, concise overview of the protocols and techniques used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. 
650 0 |a Biochemistry. 
650 0 |a Pharmacology. 
650 0 |a Medical genetics. 
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700 1 |a Peters, Jeffrey M.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
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