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The Serotonin Receptors From Molecular Pharmacology to Human Therapeutics /
The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2006.
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| Edición: | 1st ed. 2006. |
| Colección: | The Receptors,
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| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
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| 245 | 1 | 4 | |a The Serotonin Receptors |h [electronic resource] : |b From Molecular Pharmacology to Human Therapeutics / |c edited by Bryan L. Roth. |
| 250 | |a 1st ed. 2006. | ||
| 264 | 1 | |a Totowa, NJ : |b Humana Press : |b Imprint: Humana, |c 2006. | |
| 300 | |a XVIII, 618 p. 82 illus., 5 illus. in color. |b online resource. | ||
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| 490 | 1 | |a The Receptors, |x 2524-6488 | |
| 505 | 0 | |a Molecular Biology and Genomic Organization of G Protein-Coupled Serotonin Receptors -- Structure and Function Reveal Insights in the Pharmacology of 5-HT Receptor Subtypes -- Polymorphic and Posttranscriptional Modifications of 5-HT Receptor Structure -- Strategies for the Development of Selective Serotonergic Agents -- 5-HT Receptor Signal Transduction Pathways -- Agonist-Directed Trafficking of 5-HT Receptor-Mediated Signal Transduction -- Identification of 5-HT2 and 5-HT4 Receptor-Interacting Proteins -- 5-HT Receptor-Associated Proteins (FRAPs) -- Cellular and Subcellular Localization of Serotonin Receptors in the Central Nervous System -- Chemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian Brain -- Modulation of the Neuronal Activity and Neurotransmitter Release by 5-HT1A and 5-HT1B/1D Receptors -- Electrophysiology of 5-HT2A Receptors and Relevance for Hallucinogen and Atypical Antipsychotic Drug Actions -- The Emergence of 5-HT2B Receptors as Targets to Avoid in Designing and Refining Pharmaceuticals -- The 5-HT3 Receptor -- 5-HT3 and 5-HT4 Receptors as Targets for Drug Discovery for Dementia -- Electrophysiological Properties of G?s-Coupled 5-HT Receptors (5-HT4, 5-HT6, 5-HT7) -- 5-HT6 Receptors as Targets for the Treatment of Cognitive Deficits in Schizophrenia -- 5-HT7 Receptors as Favorable Pharmacological Targets for Drug Discovery -- Serotonin System Gene Knockouts -- Effects of Serotonin-Related Gene Deletion on Measures of Anxiety, Depression, and Neurotransmission. | |
| 520 | |a The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, leading experts comprehensively examine our current understanding of the molecular and structural biology of 5-HT receptors and their pharmacological use. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction. Comprehensive and state of the art, The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics provides an illuminating "snapshot" of the 5-HT receptor field today and prospects for the future, taking it from the genomic to a systems level of understanding. | ||
| 650 | 0 | |a Pharmacy. | |
| 650 | 1 | 4 | |a Pharmacy. |
| 700 | 1 | |a Roth, Bryan L. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
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| 776 | 0 | 8 | |i Printed edition: |z 9781617376474 |
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