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The Serotonin Receptors From Molecular Pharmacology to Human Therapeutics /

The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Roth, Bryan L. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Totowa, NJ : Humana Press : Imprint: Humana, 2006.
Edición:1st ed. 2006.
Colección:The Receptors,
Temas:
Acceso en línea:Texto Completo
Descripción
Sumario:The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, leading experts comprehensively examine our current understanding of the molecular and structural biology of 5-HT receptors and their pharmacological use. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction. Comprehensive and state of the art, The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics provides an illuminating "snapshot" of the 5-HT receptor field today and prospects for the future, taking it from the genomic to a systems level of understanding.
Descripción Física:XVIII, 618 p. 82 illus., 5 illus. in color. online resource.
ISBN:9781597450805
ISSN:2524-6488