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The Orexin/Hypocretin System Physiology and Pathophysiology /
Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatment...
| Clasificación: | Libro Electrónico |
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| Autor Corporativo: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2005.
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| Edición: | 1st ed. 2005. |
| Colección: | Contemporary Clinical Neuroscience,
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| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- History
- History and Overview of Orexin/Hypocretin Research
- Overview of the Orexin/Hypocretin Neuronal System
- Orexin and Orexin Receptors
- Orexin Projections and Localization of Orexin Receptors
- Neuronal Responses to Hypocretin/Orexin
- Afferent System of Orexin Neurons
- Assessment of Orexin/Hypocretin Functions in Tissue and Biological Fluids
- Hypocretin Measurements in the CSF, and Blood and Brain Tissue
- Hypocretin Receptor-Activated G Proteins Revealed by [35S]GTP?S Autoradiography
- Physiology
- Orexin System and Feeding Behavior
- Orexins and the Autonomic Nervous System
- Neuroendocrine Role of the Orexins (Hypocretins)
- The Orexin/Hypocretin System and Stress and Emotion
- Physiology
- Hypocretin as a Wakefulness Regulatory Peptide
- Hypocretin/Orexin Tonus and Vigilance Control
- Hypocretin System and Aminergic and Cholinergic Systems in the Control of Vigilance
- Orexin and Hypothalamic Control of Sleep and Waking
- Hypocretin/Orexin and Motor Function
- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency
- Overview of Human Narcolepsy
- Canine Models of Narcolepsy
- Rodent Models of Human Narcolepsy-Cataplexy
- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency
- Hypocretin Deficiency in Human Narcolepsy
- Hypocretin Status in Neurological Disorders in Relation to Excessive Sleepiness and Cataplexy
- Hypocretin Measures in Psychiatric Disorders
- Neuroendocrinology of Human Narcolepsy
- Narcolepsy and Autoimmunity
- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency
- Pharmacology of Hypocretin/Orexin Peptides and Small Molecules
- Rescue of Narcoleptic Orexin Neuron-Ablated Mice by Ectopic Overexpression of Orexin Peptides
- Hypocretin/Orexin Replacement Therapy in Hypocretin/Orexin-Deficient Narcolepsy.