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Thyroid Hormone Disruption and Neurodevelopment

Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action h...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Koibuchi, Noriyuki (Editor ), Yen, Paul M. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2016.
Edición:1st ed. 2016.
Colección:Contemporary Clinical Neuroscience,
Temas:
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Section 1: Disruption of thyroid hormone action at molecular level
  • 1 Molecular mechanisms of thyroid hormone action in brain: a general overview
  • 2 Deoidinases and brain development
  • 3 Disruption of thyroid hormone receptor-mediated action in brain by endocrine disrupting chemicals
  • 4 Chemical disruption of deiodinase activities during pregnancy and fetal neurotoxicity
  • 5 Effect of maternal/neonatal infection on thyroid hormone-mediated neurodevelopment
  • 6 Disruption of feedback regulation of thyroid hormone synthesis/secretion and brain development
  • Section 2: Animal models to study thyroid hormone disruption on neurodevelopment
  • 7 Animal models to study thyroid hormone action in neurodevelopment
  • 8 Thyroid hormone receptor mutation and neurodevelopment
  • 9 Pax6 knockout and cerebellar development
  • 10 Disruption of auditory function by thyroid hormone receptor mutation
  • Section 3 Thyroid hormone disruption and neurodevelopment: human studies
  • 11 Maternal hypothyroidism and brain development of newborns
  • 12 Congenital hypothyroidism and neurodevelopment
  • 13 Iodine deficiency and brain development
  • 14 Deficit in thyroid hormone transporters and brain development
  • 15 Syndrome of resistance to thyroid hormone and brain development.