Genome Editing The Next Step in Gene Therapy /

This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-str...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Cathomen, Toni (Editor ), Hirsch, Matthew (Editor ), Porteus, Matthew (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2016.
Edición:1st ed. 2016.
Colección:Advances in Experimental Medicine and Biology, 895
Temas:
Medical genetics.
Medical Genetics.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • 1. Gene Editing: Double-Strand Break Induced Gene Targeting and Mutagenesis 20 Years Later
  • 2. The Development and Use of Zinc-Finger Nucleases
  • 3.The Use and Development of TAL Effector Nucleases
  • 4. Genome Editing for Neuromuscular Diseases
  • 5. Phage Integrases for Genome Editing
  • 6. Precise Genome Modification Using Triplex Forming Oligonucleotides and Peptide Nucleic Acids
  • 7. Genome Editing by Aptamer-Guided Gene Targeting
  • 8. Stimulation of AAV Gene Editing via DSB Repair
  • 9. Engineered Nucleases and Trinucleotide Repeat Diseases
  • 10. Using Engineered Nucleases to Create HIV-Resistant Cells
  • 11. Strategies to Determine Off-Target Effects of Engineered Nucleases.

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