Assessing Rare Variation in Complex Traits Design and Analysis of Genetic Studies /

This unique volume is the first to cover a wide range of design and analysis issues in genetic studies of rare variants, with contributions from experts in the field, through large-scale international consortia including the UK10K Project, GO-T2D and T2D-GENES. The book presents state-of-the-art met...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Zeggini, Eleftheria (Editor ), Morris, Andrew (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2015.
Edición:1st ed. 2015.
Temas:
Medical genetics.
Medicine-Research.
Biology-Research.
Biometry.
Medical Genetics.
Biomedical Research.
Biostatistics.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Calling Rare Variants from Genotype Data
  • Calling Variants from Sequence Data
  • Rare Variant Quality Control
  • Rare Structural Variants
  • Functional Annotation of Rare Genetic Variants
  • The 1000 Genomes Project
  • The UK10K Project
  • Population Isolates
  • Natural Selection at Rare Variants
  • Collapsing Approaches for the Association Analysis of Rare Variants
  • Rare Variant Association Analysis: Beyond Collapsing Approaches
  • Significance Thresholds for Rare Variant Signals
  • Power of Rare Variant Aggregate Tests
  • Replicating Sequence-based Association Studies of Rare Variants
  • Meta-analysis of Rare Variants
  • Population Stratification of Rare Variants
  • Use of Appropriate Controls in Rare Variant Studies
  • Trans-ethnic Fine-mapping of Rare Causal Variants.

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