A Systems Biology Approach to Blood

The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Corey, Seth Joel (Editor ), Kimmel, Marek (Editor ), Leonard, Joshua N. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2014.
Edición:1st ed. 2014.
Colección:Advances in Experimental Medicine and Biology, 844
Temas:
Medicine-Research.
Biology-Research.
Bioinformatics.
Hematology.
Biomedical Research.
Computational and Systems Biology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Part I: Basic Components
  • Systems Hematology:  An Introduction
  • Quantification and Modeling of Stem Cell - Niche Interaction
  • Angiogenesis: A Systems Biology View of Blood Vessel Remodeling
  • Erythropoiesis: From Molecular Pathways to System Properties
  • Systems Biology of Megakaryocytes
  • Systems Biology of Platelet-Vessel Wall Interactions
  • Systems Approach to Phagoycte Production and Activation: Neutrophils and Monocytes
  • Part II: Physiological Processes
  • Stochasticity and Determinism in Models of Hematopoiesis
  • Systems Analysis of High-Throughput Data
  • Developing a Systems-Based Understanding of Hematopoietic Stem Cell Cycle Control
  • A Systems Biology Approach to Iron Metabolism
  • Innate Immunity in Disease - Insights from Mathematical Modeling and Analysis
  • Modeling Biomolecular Site Dynamics in Immunoreceptor Signaling Systems
  • Structure and Function of Platelet Receptors Initiating Blood Clotting
  • Part III: Clinical Applications
  • Understanding and Treating Cytopenia through Mathematical Modeling
  • Drug Resistance
  • Etiology and Treatment of Hematological Neoplasms: Stochastic Mathematical Models
  • Assessing Hematopoietic (Stem-) Cell Behavior during Regenerative Pressure
  • Engineered Cell-Based Therapies: A Vanguard of Design-Driven Medicine
  • Part IV: Epilogue
  • A Systems Approach to Blood Disorders
  • Index.

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