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Humanized Mice for HIV Research
Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have de...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | , , , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York, NY :
Springer New York : Imprint: Springer,
2014.
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| Edición: | 1st ed. 2014. |
| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- Mamoru Ito's Vision for the Future of Humanized Mouse Models
- Part I. Mouse genetic background and human hematopoietic stem cells biology
- Humanized Mice as Models for Human Disease
- Role of mouse innate immunity in immunodeficient mice for xenotransplantation
- Mouse genetic background and human hematopoietic stem cells biology; tips for humanization
- Biology of Human Hematopoietic Stem Cell Xenotransplantation in Mice
- Impact of the mouse IL-2Rg chain on lymphoid tissue development and human reconstitution in immunodeficient mice
- BM hematopoietic niche occupancy defect of HSC in scid mice
- Improvement of human multilineage hematopoietic engraftment by cytokine knockin replacement in human-hemato-lymphoid system mice
- Part II. SECTION 2: Understanding of human immune cells development and function in mouse environment
- Cytokine species-specificity and humanized mice
- Human T cell biology in a mouse environment
- Thymic education of human T cells and regulatory T cell development in humanized mice
- Human B cell development in a mouse environment
- The analysis of the functions of human B and T cells in humanized NOG mice
- NK cell development in human immune system (HIS) mice and their role in HIV pathogenesis
- Maintenance and function of human CD8+ T cells and NK cells in humanized mice
- Phenotypical and functional properties of antigen-presenting cells derived from humanized mice
- Part III: Humanized mice for HIV-1 virus biology and pathogenesis. Is it possible to address?
- Humanized mouse versus non-human primate models of HIV-1 infection
- Host factor-mediated resistance to HIV-1 infection
- Vaginal and Rectal HIV Transmission in Humanized Mice
- Oral HIV-1 Transmission in BLT Humanized Mice
- Selective infection of CD4+ memory T cells
- Development and function of human CD4+CD25+FOXP3+ regulatory T cells in humanized mouse and HIV-1 infection
- Role of TLR signaling in HIV-1-induced adaptive immune activation
- Latent HIV-1 infection of resting CD4+ T cells: Testing approaches to overcome HIV latency
- Brain HIV-1 infection modeling in humanized mice
- Part IV. Humanized mice for HIV-1-specific adaptive cellular and humoral immune responses
- Antibody-based protection against HIV infection
- B-cell responses in humanized mice: the glass is half full
- Part V. Therapeutics developments for HIV-1
- Species similarities and differences in pharmacokinetics and distribution of antiretroviral drugs
- Anti-Retroviral Treatment Testing in HIV-Infected Humanized Mice
- Humanized Mice as a Platform for the Development of Long-Acting Nanoformulated Antiretroviral Therapy
- Targeted delivery of aptamers and siRNAs for HIV prevention and therapies in humanized mice
- Zinc finger nuclease editing of hematopoietic stem cells as an anti-HIV therapy
- Hematopoietic progenitor cell transduction by a unique short hairpin RNA to chemokine receptor 5
- Cell-based approaches for treating HIV infection
- A conditionally replicating human immunodeficiency virus in BRG-HIS mice
- Part VI. New models for other human-specific or human selective pathogens
- Dual reconstituted mice for hepatotropic pathogens
- Dengue viral pathogenesis and immune responses in humanized mice
- HIV-1 and TB: How Humanized Mice Can Help
- Epstein-Barr Virus Infection in Humanized Mice
- HTLV-1 infection of humanized NOD/SCID IL2 gc-/- and BALB/c-Rag2-/-gc-/- mouse models
- Plasmodium falciparum parasite development in humanized mice: liver and blood stages
- Part VII. New horizons in mouse humanization
- The Future is NOW for Humanized Mouse Models.