Cardiac Energy Metabolism in Health and Disease

The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP.  The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy, and any change...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Lopaschuk, Gary D. (Editor ), Dhalla, Naranjan S. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2014.
Edición:1st ed. 2014.
Colección:Advances in Biochemistry in Health and Disease, 11
Temas:
Biochemistry.
Bioinformatics.
Cardiology.
Computational and Systems Biology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Part 1. Control of Energy Metabolism
  • 1. A Primer on Carbohydrate Metabolism in the Heart
  • 2. Lipoproteins: A Source of Cardiac Lipids
  • 3. Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart
  • 4. Control of Myocardial Fatty Acid Uptake
  • 5. Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes
  • 6. Transcriptional Control of Mitochondrial Biogenesis and Maturation
  • 7. Relationship between Substrate Metabolism and Cardiac Efficiency
  • 8. Acetylation in the Control of Mitochondrial Metabolism and Integrity
  • Part 2. Alteration in Energy Metabolism
  • 9. Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes
  • 10. The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heart
  • 11. Fuel Metabolism Plasticity in Pathological Cardiac Hypertrophy and Failure
  • 12. Defects in Mitochondrial Oxidative Phosphorylation in Hearts Subjected to Ischemia-Reperfusion Injury
  • 13. The Role of AMPK in the Control of Cardiac Hypertrophy
  • 14. The Role of Incomplete Fatty Acid Oxidation in the Development of Cardiac Insulin Resistance
  • Part 3. Optimization of Energy Metabolism
  • 15. Metabolic Therapy for the Ischemic Heart
  • 16. Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients
  • 17. Cardiac Metabolic Protection for the Newborn Heart
  • 18. Targeting Transcriptional Control of Fatty Acid Oxidation to Treat Heart Disease.

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