Hypoxia and Cancer Biological Implications and Therapeutic Opportunities /

The tremendous progress in our understanding of the molecular mechanisms underlying tumor hypoxias has generated a great deal of enthusiasm and provides new opportunities to better understand and target the tumor microenvironment. This book emphasizes how changes in oxygen levels in the tumor microe...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Melillo, Giovanni (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Humana, 2014.
Edición:1st ed. 2014.
Colección:Cancer Drug Discovery and Development,
Temas:
Cancer.
Medicine-Research.
Biology-Research.
Pharmacology.
Stem cells.
Cancer Biology.
Biomedical Research.
Stem Cell Biology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Preface
  • Hypoxia and breast cancer metastasis
  • Hypoxia and the DNA damage response
  • Hypoxia and non-coding RNAs
  • Hypoxia and ROS
  • Hypoxia and gene expression
  • Carbonic anhydrase IX: from biology to therapy
  • Imaging the hypoxic tumor microenvironment in preclinical models
  • Clinical imaging of hypoxia
  • Hypoxia, antiangiogenic therapy and metastasis
  • UPR and therapeutic opportunities
  • Targeting the hypoxic phenotype
  • Marianne Nordsmark: Hypoxia and Radiation therapy
  • Pharmacological strategies targeting hypoxia
  • Targeting the hypoxic tumor microenvironment
  • Clinical exploitation of hypoxia
  • Index.

Ejemplares similares