Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an in...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Rudek, Michelle A. (Editor ), Chau, Cindy H. (Editor ), Figg, William D. (Editor ), McLeod, Howard L. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Humana, 2014.
Edición:2nd ed. 2014.
Colección:Cancer Drug Discovery and Development,
Temas:
Pharmacy.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • 1. Molecular Targets
  • 2. Preclinical Screening for New Anticancer Agents
  • 3. Natural Product Screening
  • 4. Defining the Starting Dose: Should it be mg/kg, mg/m2 or Fixed?
  • 5. Phase 0 Trials in Oncology
  • 6. Phase I Trials in Oncology - Design and Endpoints
  • 7. Quantitative Analytical Methods: Development and Clinical Considerations
  • 8. Validation and Control of Bioanalytical Methods
  • 9. Anti-Cancer Clinical Pharmacology Overview
  • 10. Pharmacokinetic Modeling
  • 11. Pharmacometrics
  • 12. Pharmacodynamic Modeling
  • 13. Protein Binding
  • 14. Metabolism (Non-CyP Enzymes)
  • 15. Pharmacogenomics and Cancer Therapy: Somatic and Germline Polymorphisms
  • 16. Cytochrome P450
  • 17. Polymorphisms in Genes of Drug Targets and Metabolism
  • 18. DNA Repair: ERCC1, Nucleotide Excision Repair, and Platinum Resistance
  • 19. Drug Interactions
  • 20. ABC Transporters: Involvement in Multidrug Resistance and Drug Disposition
  • 21. Solute carriers
  • 22. High Throughput Platforms in Drug Metabolism and Transport Pharmacogenetics
  • 23. Intrathecal Administration
  • 24. Microdialysis
  • 25. Regional Drug Delivery for Inoperable Pulmonary Malignancies
  • 26. Blood-Brain-Barrier & CNS Malignancy
  • 27. Radiation and Altering Clinical Pharmacology
  • 28. Therapeutic Cancer Vaccines: An Emerging Approach to Cancer Treatment
  • 29. Recombinant Immunotoxins
  • 30. Monoclonal Antibodies
  • 31. Clinical Pharmacology in Pediatrics
  • 32. Clinical Pharmacology in the Elderly
  • 33. Organ Dysfunction Trials:  Background, Historical Barriers, Progress in Overcoming Barriers and Suggestions for Future Trials
  • 34. Drug Formulations: How this Affects Anticancer Drug Pharmacokinetics and Pharmacodynamics
  • 35. Nanotechnology in Cancer
  • 36. Imaging in Drug Development
  • 37. Exposure-Response Relationship of Anticancer Agents: Application in Drug Development and Drug Label
  • 38. The Role of Phase III Trials in Modern Drug Development
  • 39. Clinical Trial Designs for Approval of New Anticancer Agents
  • 40. Clinical Pharmacogenetics.

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