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Gadd45 Stress Sensor Genes
Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York, NY :
Springer New York : Imprint: Springer,
2013.
|
| Edición: | 1st ed. 2013. |
| Colección: | Advances in Experimental Medicine and Biology,
793 |
| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
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| 001 | 978-1-4614-8289-5 | ||
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| 024 | 7 | |a 10.1007/978-1-4614-8289-5 |2 doi | |
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| 245 | 1 | 0 | |a Gadd45 Stress Sensor Genes |h [electronic resource] / |c edited by Dan A. Liebermann, Barbara Hoffman. |
| 250 | |a 1st ed. 2013. | ||
| 264 | 1 | |a New York, NY : |b Springer New York : |b Imprint: Springer, |c 2013. | |
| 300 | |a X, 134 p. 18 illus., 11 illus. in color. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a Advances in Experimental Medicine and Biology, |x 2214-8019 ; |v 793 | |
| 505 | 0 | |a Gadd45 in stress signaling, cell cycle control and apoptosis -- Gadd45 in Modulation of Solid Tumors and Leukemia -- Gadd45 Proteins: Key players of repair-mediated DNA demethylation -- Gadd45 proteins in Immunity -- Gadd45 in the liver - Signal transduction and transcriptional mechanisms -- The Role of the Gadd45 Family in the Nervous System: A focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics -- Gadd45 stress sensors in preeclampsia -- Index. | |
| 520 | |a Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved. . | ||
| 650 | 0 | |a Medical genetics. | |
| 650 | 0 | |a Biochemistry. | |
| 650 | 1 | 4 | |a Medical Genetics. |
| 650 | 2 | 4 | |a Biochemistry. |
| 700 | 1 | |a Liebermann, Dan A. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 700 | 1 | |a Hoffman, Barbara. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9781461482901 |
| 776 | 0 | 8 | |i Printed edition: |z 9781461482888 |
| 776 | 0 | 8 | |i Printed edition: |z 9781493953905 |
| 830 | 0 | |a Advances in Experimental Medicine and Biology, |x 2214-8019 ; |v 793 | |
| 856 | 4 | 0 | |u https://doi.uam.elogim.com/10.1007/978-1-4614-8289-5 |z Texto Completo |
| 912 | |a ZDB-2-SBL | ||
| 912 | |a ZDB-2-SXB | ||
| 950 | |a Biomedical and Life Sciences (SpringerNature-11642) | ||
| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||