Complex Systems and Computational Biology Approaches to Acute Inflammation

The Translational Dilemma, the difficulty in achieving effective translation of basic mechanistic biomedical knowledge into effective therapeutics, is the greatest challenge in biomedical research. Nowhere is this more apparent than in understanding and manipulating the acute inflammatory response i...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Vodovotz, Yoram (Editor ), An, Gary (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2013.
Edición:1st ed. 2013.
Temas:
Bioinformatics.
Immunology.
Medicine-Research.
Biology-Research.
Computational and Systems Biology.
Biomedical Research.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • An overview of the Translational Dilemma and the need for Translational Systems Biology of inflammation
  • Part I: Complex Systems Methods and Applications
  • Translational Equation-based Modeling
  • Agent-based Modeling in Translational Systems Biology
  • Analysis of Heart Rate Variability
  • Analysis of Ventilatory Pattern Variability
  • Part II: Translational Modeling of Sepsis and Trauma
  • Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective
  • Multi-scale equation-based models: Insights for Inflammation and Physiological Variability
  • Integrating Data Driven and Mechanistic Models of the Inflammatory Response in Sepsis and Trauma
  • In silico Trials and Personalized Therapy for Sepsis and Trauma
  • Part III: Translational Modeling of Wound Healing
  • Disorder of Localized Inflammation in Wound Healing: A Systems Perspective
  • Equation-based Models of Wound Healing and Collective Cell Migration
  • Agent-based Models of Wound Healing
  • Part IV: Translational Modeling of Host-pathogen Interactions
  • Modeling Host-Pathogen Interactions in Necrotizing Enterocolitis
  • Modeling Host-Vector-Pathogen Immuno-inflammatory Interactions in Malaria
  • Part V: Future Perspectives
  • Translation to Implementation
  • The Rationale and Implementation of Translational Systems Biology as a new Paradigm for the Study of Inflammation
  • Index.

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