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Androgen-Responsive Genes in Prostate Cancer Regulation, Function and Clinical Applications /

Recent studies demonstrated a key role of the androgen receptor in the development of castration-recurrent or -resistant prostate cancer (CRPC), which is deadly and in urgent need of more effective therapies.  Understanding the functions of androgen-responsive genes and their regulation and deregula...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Wang, Zhou (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2013.
Edición:1st ed. 2013.
Temas:
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Preface
  • Roles of androgen receptor coregulators and cell signaling in regulation of androgen-responsive genes
  • Selective and classical Androgen Response Elements in androgen-regulated gene expression
  • Negative androgen-response elements in androgen target genes
  • Chromatin looping and long distance regulation by androgen receptor
  • The Functionality of Prostate Cancer Predisposition Risk Regions is revealed by AR Enhancers
  • Mechanisms of ARE-independent Gene Activation by the Androgen Receptor in Prostate Cancer Cells: potential targets for better intervention strategies
  • Androgen action, Wnt signaling, and prostate tumorigenesis
  • Toward Revealing the Complexity of Androgen Responsive Protein and Non-coding Transcripts in Prostate Cancer
  • Androgen-Responsive Gene Expression in Prostate Cancer Progression
  • Androgen receptor regulated genes in prostate cancer initiation vs metastasis
  • Androgen-Independent Induction of Androgen-Responsive Genes By Interleukin-6 Regulation
  • The effect of AR overexpression on androgen signaling in prostate cancer
  • The expression signature of androgen receptor splice variants and their distinctive transcriptional activities in castration-resistant prostate cancer
  • Androgen regulation of the cell cycle in prostate cancer
  • Androgen Receptor Signaling Interactions Control Epithelial-Mesenchymal Transition (EMT) in Prostate Cancer Progression
  • Androgen receptor regulation of serum response factor signaling in prostate cancer
  • Regulation of angiogenesis by androgen-responsive gene EAF2
  • The role of miR-21, an androgen-regulated microRNA, in prostate cancer
  • Androgen dependent oncogenic activation of ETS transcription factors by recurrent gene fusions in prostate cancer: Biological and Clinical Implications
  • Clusterin as a target for treatment of castration-resistant prostate cancer
  • Index.