Serotonin and Anxiety Neuroanatomical, Pharmacological, and Functional Aspects /

Anxiety disorders have long been a research subject for scientists in different areas of inquiry, and the particular role of serotonin - the neurotransmitter which has probably most captured the imagination of laymen and academics alike - is as elusive as the clinical aspects of serotonergic medicat...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Maximino, Caio (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2012.
Edición:1st ed. 2012.
Colección:SpringerBriefs in Neuroscience,
Temas:
Neurosciences.
Psychiatry.
Neurology .
Neuroscience.
Neurology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Introduction and scope of the review
  • Anxiety and risk assessment
  • Fear/panic and the fight/flight/freeze system
  • "Coping" styles, stress reactivity, and the active-passive continuum
  • Serotonin in the nervous system of vertebrates
  • Synthesis and metabolism of serotonin
  • Transport of serotonin: SERT and uptake
  • Serotonin receptors
  • 5-HT1A receptors
  • 5-HT1B receptors
  • 5-HT2C receptors
  • Nodal structures in anxiety-like and panic-like responses
  • Nodal structures regulating anxiety: The behavioral inhibition system
  • "Limbic" portions of the medial prefrontal cortex
  • The extended amygdala
  • The ventral hippocampus
  • The lateral habenula
  • Nodal structures regulating panic: The cerebral aversive system
  • The central amygdala
  • The medial hypothalamic defense system
  • The mesopontine rostromedial tegmental nucleus
  • The periaqueductal gray area
  • Locus coeruleus
  • The dual role hypothesis
  • Destruction or blockade of DRN neurons is anxiolytic and panicogenic
  • The defensive context for increased serotonin release
  • Topographic organization of DRN. - The dorsal portion of the DRN is part of a mesocorticolimbic system involved in anxiety-like responses
  • The caudal portion of the DRN is highly responsive to stress-related peptides
  • The lateral wings of the DRN are involved in panic-like responses
  • General conclusions.

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