Adenosine A Key Link between Metabolism and Brain Activity /

Homeostasis of key metabolites and metabolic health affects all bodily systems.  Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system - including developmental disorders, acute nervous system injury, and neurodegenerative disor...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Masino, Susan (Editor ), Boison, Detlev (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2013.
Edición:1st ed. 2013.
Temas:
Neurosciences.
Neuroscience.
Acceso en línea:Texto Completo

MARC

LEADER 00000nam a22000005i 4500
001 978-1-4614-3903-5
003 DE-He213
005 20220112190110.0
007 cr nn 008mamaa
008 120829s2013 xxu| s |||| 0|eng d
020 |a 9781461439035  |9 978-1-4614-3903-5 
024 7 |a 10.1007/978-1-4614-3903-5  |2 doi 
050 4 |a RC321-580 
072 7 |a PSAN  |2 bicssc 
072 7 |a MED057000  |2 bisacsh 
072 7 |a PSAN  |2 thema 
082 0 4 |a 612.8  |2 23 
245 1 0 |a Adenosine  |h [electronic resource] :  |b A Key Link between Metabolism and Brain Activity /  |c edited by Susan Masino, Detlev Boison. 
250 |a 1st ed. 2013. 
264 1 |a New York, NY :  |b Springer New York :  |b Imprint: Springer,  |c 2013. 
300 |a XVI, 680 p.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
505 0 |a Adenosine and metabolism - a brief historical note -- Adenosine metabolism, adenosine kinase and evolution -- Adenosine and energy metabolism - relationship to brain bioenergetics -- Adenosine and autocrine metabolic regulation of neuronal activity -- Physiologic and metabolic regulation of adenosine - mechanisms -- The double edged sword: gaining adenosine at the expense of ATP. How to balance the books -- Downstream pathways of adenosine -- Astrocytic ATP release -- Role of striatal A2A receptor subpopulations in neurological disorder -- Sleep and adenosine: human studies -- Adenosine and Other Purinergic Products in Circadian Timing -- Adenosine in the immune system -- The bioenergetics network of adenosine in hibernation, sleep and thermoregulation -- Adenosine and stroke -- The many roles of adenosine in traumatic brain injury -- Therapeutic Perspectives of Adenosine Receptor Compounds in Functional Restitutions after Spinal Cord Injury -- Adenosine and pain -- Symptomatic and neuroprotective effects of A2A receptor antagonists in Parkinson's Disease -- Adenosine receptors and Alzheimer's Disease -- Adenosine receptors in Huntington's Disease -- Adenosine and Multiple Sclerosis -- Adenosinergic perspectives on schizophrenia - Opportunity for an integrative synthesis -- The role of adenosine in the ventral striatal circuits regulating behavioral activation and effort-related decision making: Importance for normal and pathological aspects of motivation -- Adenosine and autism:  Physiological symptoms and metabolic opportunities -- Stress, Brain Adenosine Signaling, and Fatigue-Related Behavioral Processes -- Disruption of adenosine homeostasis in epilepsy and therapeutic adenosine augmentation -- Ketogenic Diet and Epilepsy: The Role of Adenosine -- Silk - a biocompatible and biodegradable biopolymer for therapeutic adenosine delivery -- Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy. 
520 |a Homeostasis of key metabolites and metabolic health affects all bodily systems.  Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system - including developmental disorders, acute nervous system injury, and neurodegenerative disorders.  Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions.  Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition.  Adenosine:  A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system.  Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism.  At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression.  Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function.  Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders.  This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders. 
650 0 |a Neurosciences. 
650 1 4 |a Neuroscience. 
700 1 |a Masino, Susan.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
700 1 |a Boison, Detlev.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer Nature eBook 
776 0 8 |i Printed edition:  |z 9781461439028 
776 0 8 |i Printed edition:  |z 9781489987556 
776 0 8 |i Printed edition:  |z 9781461439042 
856 4 0 |u https://doi.uam.elogim.com/10.1007/978-1-4614-3903-5  |z Texto Completo 
912 |a ZDB-2-SBL 
912 |a ZDB-2-SXB 
950 |a Biomedical and Life Sciences (SpringerNature-11642) 
950 |a Biomedical and Life Sciences (R0) (SpringerNature-43708) 

Ejemplares similares